Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.
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چکیده
منابع مشابه
Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.
Narcotics affect adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in two opposing ways, both mediated by the opiate receptor. The first process is the readily reversible inhibition of the enzyme by narcotics; the second is a compensatory increase in enzyme activity which is delayed in onset and relatively stable. Late positive regulation of the enzyme counteracts the inhibito...
متن کاملNarcotic tolerance and dependence and serotonin turnover.
stimuli. Access to and copulation with the females was accompanied by becoming the alpha, or dominant, male in a new group. It is possible that the latter experience isa provocative stimulus to increased testosterone secretion, along with frequent sexual activity. Studies are needed to clarify this issue. With more indirect techniques of assessing testosterone secretion, such as measurement of ...
متن کاملNarcotic Tolerance and Dependence and Serotonin Turnover
stimuli. Access to and copulation with the females was accompanied by becoming the alpha, or dominant, male in a new group. It is possible that the latter experience isa provocative stimulus to increased testosterone secretion, along with frequent sexual activity. Studies are needed to clarify this issue. With more indirect techniques of assessing testosterone secretion, such as measurement of ...
متن کاملE VALUATION OF ADENYLATE CYCLASE ACTIVITY IN MITRAL VALVE PROLAPSE
The term mitral valve prolapse (MVP) is used for a particular subset of patients with hyperadrenergic dysautonomia. It occurs when part of a leaflet or both leaflets of the mitral valve extend above the plane of the atrioventricular junction during ventricular systole. The adenylate cyclase activity in MVP dys-autonomia was studied by extraction of enzyme from the erythrocytes from 62 norma...
متن کاملAdenylate cyclase from Brevibacterium liquefaciens. III. In situ regulation of adenylate cyclase by pyruvate.
In the presence of DL-alanine intracellular cyclic AMP in nonproliferating cells of Brevibacterium liquefaciens increased rapidly to the maximum level of approximately 180 muM, and extracellular cyclic AMP increased to 100 muM within 4 hr at 25 degrees . Adenylate cyclase (EC 4.6.1.1) induction was not observed during this incubation. The concentration of pyruvate in the total culture increased...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1975
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.72.8.3092